XPG (ERCC5) (NM_000123) Human Recombinant Protein

• Background:

  This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, cognitive disability, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene. [provided by RefSeq, Feb 2011]

• Synonyms:

  COFS3; ERCC5-201; ERCM2; UVDR; XPG; XPGC

• Gene ID:

  2073

• UniProt:

  P28715

• Accession Number mRNA:

  NM_000123

• Chromosomal Location:

  13q33.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Nucleotide excision repair

• Field of Research:

  Nucleotide excision repair

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Stem cell - Pluripotency, Transcription Factors

• Molecular Weight:

  133.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ERCC5

• Species:

  Human

• Protein ID:

  NP_000114

• Overview:

  Recombinant protein of human excision repair cross-complementing rodent repair deficiency, complementation group 5 (ERCC5)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/2073

• Uniprot URL:

  https://www.uniprot.org/uniprot/P28715

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000123

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000114