PMVK (NM_006556) Human Recombinant Protein

• Background:

  This gene encodes a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. The encoded protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis. Mutations in this gene are linked to certain types of porokeratosis including disseminated superficial porokeratosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

• Synonyms:

  HUMPMKI; PMK; PMKA; PMKASE; POROK1

• Gene ID:

  10654

• UniProt:

  Q15126, Q6FGV9

• Accession Number mRNA:

  NM_006556

• Chromosomal Location:

  1q21.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Metabolic pathways, Terpenoid backbone biosynthesis

• Field of Research:

  Metabolic pathways, Terpenoid backbone biosynthesis

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  21.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PMVK

• Species:

  Human

• Protein ID:

  NP_006547

• Overview:

  Recombinant protein of human phosphomevalonate kinase (PMVK)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/10654

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q15126

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_006556

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_006547