Glutathione Synthetase (GSS) (NM_000178) Human Recombinant Protein

• Background:

  Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq, Jul 2008]

• Synonyms:

  GSHS; HEL-S-64p; HEL-S-88n

• Gene ID:

  2937

• UniProt:

  P48637, V9HWJ1

• Accession Number mRNA:

  NM_000178

• Chromosomal Location:

  20q11.22

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Glutathione metabolism, Metabolic pathways

• Field of Research:

  Glutathione metabolism, Metabolic pathways

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  52.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  GSS

• Species:

  Human

• Protein ID:

  NP_000169

• Overview:

  Recombinant protein of human glutathione synthetase (GSS)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/2937

• Uniprot URL:

  https://www.uniprot.org/uniprot/P48637

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000178

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000169