TCP1 epsilon (CCT5) (NM_012073) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC) . This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP) . Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]

• Synonyms:

  CCT-epsilon; CCTE; HEL-S-69; PNAS-102; TCP-1-epsilon

• Gene ID:

  22948

• UniProt:

  P48643, V9HW37

• Accession Number mRNA:

  NM_012073

• Chromosomal Location:

  5p15.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  59.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CCT5

• Species:

  Human

• Protein ID:

  NP_036205

• Overview:

  Recombinant protein of human chaperonin containing TCP1, subunit 5 (epsilon) (CCT5)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/22948

• Uniprot URL:

  https://www.uniprot.org/uniprot/P48643

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_012073

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_036205