SAV1 (NM_021818) Human Recombinant Protein

• Background:

  WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1) -associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012]

• Synonyms:

  SAV; WW45; WWP4

• Gene ID:

  60485

• UniProt:

  Q9H4B6

• Accession Number mRNA:

  NM_021818

• Chromosomal Location:

  14q22.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  44.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  SAV1

• Species:

  Human

• Protein ID:

  NP_068590

• Overview:

  Recombinant protein of human salvador homolog 1 (Drosophila) (SAV1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/60485

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9H4B6

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_021818

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_068590