NNT1 (CLCF1) (NM_013246) Human Recombinant Protein

• Background:

  This gene is a member of the glycoprotein (gp) 130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1) . CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1) . This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2) . This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]

• Synonyms:

  BSF-3; BSF3; CISS2; CLC; NNT-1; NNT1; NR6

• Gene ID:

  23529

• UniProt:

  Q9UBD9

• Accession Number mRNA:

  NM_013246

• Chromosomal Location:

  11q13.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

• Field of Research:

  Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Secreted Protein

• Molecular Weight:

  25 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CLCF1

• Species:

  Human

• Protein ID:

  NP_037378

• Overview:

  Recombinant protein of human cardiotrophin-like cytokine factor 1 (CLCF1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/23529

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9UBD9

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_013246

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_037378