HNF1 beta (HNF1B) (NM_000458) Human Recombinant Protein

• Background:

  This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

• Synonyms:

  ADTKD3; FJHN; HNF-1-beta; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3; LFB3; MODY5; RCAD; T2D; TCF-2; TCF2; VHNF1

• Gene ID:

  6928

• UniProt:

  P35680, Q6FHW6

• Accession Number mRNA:

  NM_000458

• Chromosomal Location:

  17q12

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Maturity onset diabetes of the young

• Field of Research:

  Maturity onset diabetes of the young

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Transcription Factors

• Molecular Weight:

  61.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  HNF1B

• Species:

  Human

• Protein ID:

  NP_000449

• Overview:

  Recombinant protein of human HNF1 homeobox B (HNF1B)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/6928

• Uniprot URL:

  https://www.uniprot.org/uniprot/P35680

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000458

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000449