HNF1 alpha (HNF1A) (NM_000545) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

• Synonyms:

  HNF-1A; HNF1; HNF1alpha; HNF4A; IDDM20; LFB1; MODY3; TCF-1; TCF1

• Gene ID:

  6927

• UniProt:

  P20823, E0YMI7

• Accession Number mRNA:

  NM_000545

• Chromosomal Location:

  12q24.31

• Expression System:

  HEK293

• Tag:

  C-Myc/DDK

• Related Pathways:

  Maturity onset diabetes of the young

• Field of Research:

  Maturity onset diabetes of the young

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Adult stem cells, Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors

• Molecular Weight:

  67.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  HNF1A

• Species:

  Human

• Protein ID:

  NP_000536

• Overview:

  Purified recombinant protein of Human HNF1 homeobox A (HNF1A), mutant (C236S), expressed in HEK293 cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/6927

• Uniprot URL:

  https://www.uniprot.org/uniprot/P20823

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000545

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000536