CCN5 (NM_003881) Human Recombinant Protein

• Background:

  This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008]

• Synonyms:

  CT58; CTGF-L; WISP2

• Gene ID:

  8839

• UniProt:

  O76076

• Accession Number mRNA:

  NM_003881

• Chromosomal Location:

  20q13.12

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein

• Molecular Weight:

  24.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CCN5

• Species:

  Human

• Protein ID:

  NP_003872

• Overview:

  Recombinant protein of human WNT1 inducible signaling pathway protein 2 (WISP2)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/8839

• Uniprot URL:

  https://www.uniprot.org/uniprot/O76076

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_003881

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_003872