FGD1 (NM_004463) Human Recombinant Protein

• Background:

  This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of the faciogenital dysplasia in Aarskog-Scott syndrome and a syndromatic form of X-linked cognitive disability. [provided by RefSeq, Jul 2017]

• Synonyms:

  AAS; FGDY; MRXS16; ZFYVE3

• Gene ID:

  2245

• UniProt:

  P98174, A0A024R9Y5

• Accession Number mRNA:

  NM_004463

• Chromosomal Location:

  Xp11.22

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Regulation of actin cytoskeleton

• Field of Research:

  Regulation of actin cytoskeleton

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  106.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  FGD1

• Species:

  Human

• Protein ID:

  NP_004454

• Overview:

  Recombinant protein of human FYVE, RhoGEF and PH domain containing 1 (FGD1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/2245

• Uniprot URL:

  https://www.uniprot.org/uniprot/P98174

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_004463

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_004454