Fgd1 (NM_008001) Mouse Recombinant Protein

• Background:

  This gene encodes a member of family of Rho-specific guanine nucleotide exchange factors. Rho-specific guanine nucleotide exchange factors catalyze the exchange of GDP for GTP and activate small GTPases, which function as molecular switches in signaling. This protein specifically binds cell division cycle 42, a Rho (Ras homology) GTPase. Investigations in mouse suggest that this protein is important for skeletal mineralization and for regulating the actin cytoskeleton. In humans, mutations in this gene are associated with faciogenital dysplasia, also known as Aarskog-Scott syndrome. [provided by RefSeq, Mar 2014]

• Synonyms:

  ZFYVE; ZFYVE3

• Gene ID:

  14163

• UniProt:

  P52734, Q3UG32

• Accession Number mRNA:

  NM_008001

• Chromosomal Location:

  X 68.46 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  106.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Fgd1

• Species:

  Mouse

• Protein ID:

  NP_032027

• Overview:

  Purified recombinant protein of Mouse FYVE, RhoGEF and PH domain containing 1 (Fgd1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/14163

• Uniprot URL:

  https://www.uniprot.org/uniprot/P52734

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_008001

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_032027