PIP5K2 alpha (PIP4K2A) (NM_005028) Human Recombinant Protein

• Background:

  Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008]

• Synonyms:

  PI5P4KA; PIP5K2A; PIP5KII-alpha; PIP5KIIA; PIPK

• Gene ID:

  5305

• UniProt:

  P48426

• Accession Number mRNA:

  NM_005028

• Chromosomal Location:

  10p12.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Inositol phosphate metabolism, Phosphatidylinositol signaling system, Regulation of actin cytoskeleton

• Field of Research:

  Inositol phosphate metabolism, Phosphatidylinositol signaling system, Regulation of actin cytoskeleton

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  46 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PIP4K2A

• Species:

  Human

• Protein ID:

  NP_005019

• Overview:

  Recombinant protein of human phosphatidylinositol-5-phosphate 4-kinase, type II, alpha (PIP4K2A)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5305

• Uniprot URL:

  https://www.uniprot.org/uniprot/P48426

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_005028

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_005019