Pip4k2a (NM_008845) Mouse Recombinant Protein

• Background:

  Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns (4,5) P2) . May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P (By similarity) . May be involved in thrombopoiesis and the terminal maturation of megakaryocytes and regulation of their size.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  AW742916; Pip5k2a

• Gene ID:

  18718

• UniProt:

  O70172, Q544E3

• Accession Number mRNA:

  NM_008845

• Chromosomal Location:

  2 A3

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  46.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Pip4k2a

• Species:

  Mouse

• Protein ID:

  NP_032871

• Overview:

  Purified recombinant protein of Mouse phosphatidylinositol-5-phosphate 4-kinase, type II, alpha (Pip4k2a), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/18718

• Uniprot URL:

  https://www.uniprot.org/uniprot/O70172

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_008845

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_032871