BMPR1A (NM_004329) Human Recombinant Protein

• Background:

  The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]

• Synonyms:

  10q23del; ACVRLK3; ALK3; CD292; SKR5

• Gene ID:

  657

• UniProt:

  P36894

• Accession Number mRNA:

  NM_004329

• Chromosomal Location:

  10q23.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Cytokine-cytokine receptor interaction, TGF-beta signaling pathway

• Field of Research:

  Cytokine-cytokine receptor interaction, TGF-beta signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane

• Molecular Weight:

  57.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  BMPR1A

• Species:

  Human

• Protein ID:

  NP_004320

• Overview:

  Recombinant protein of human bone morphogenetic protein receptor, type IA (BMPR1A)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/657

• Uniprot URL:

  https://www.uniprot.org/uniprot/P36894

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_004329

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_004320