Exodus 2 (CCL21) (NM_002989) Human Recombinant Protein

• Background:

  This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19) . [provided by RefSeq, Sep 2014]

• Synonyms:

  6Ckine; CKb9; ECL; SCYA21; SLC; TCA4

• Gene ID:

  6366

• UniProt:

  O00585, Q6ICR7

• Accession Number mRNA:

  NM_002989

• Chromosomal Location:

  9p13.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Chemokine signaling pathway, Cytokine-cytokine receptor interaction

• Field of Research:

  Chemokine signaling pathway, Cytokine-cytokine receptor interaction

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Secreted Protein

• Molecular Weight:

  12.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CCL21

• Species:

  Human

• Protein ID:

  NP_002980

• Overview:

  Recombinant protein of human chemokine (C-C motif) ligand 21 (CCL21)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/6366

• Uniprot URL:

  https://www.uniprot.org/uniprot/O00585

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_002989

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_002980