RAP2A (NM_021033) Human Recombinant Protein

• Background:

  Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  K-REV; KREV; RAP2; RbBP-30

• Gene ID:

  5911

• UniProt:

  P10114

• Accession Number mRNA:

  NM_021033

• Chromosomal Location:

  13q32.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  20.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  RAP2A

• Species:

  Human

• Protein ID:

  NP_066361

• Overview:

  Recombinant protein of human RAP2A, member of RAS oncogene family (RAP2A)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5911

• Uniprot URL:

  https://www.uniprot.org/uniprot/P10114

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_021033

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_066361