CIAP2 (BIRC3) (NM_001165) Human Recombinant Protein

• Background:

  This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]

• Synonyms:

  AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1; IAP-1; MALT2; MIHC; RNF49

• Gene ID:

  330

• UniProt:

  Q13489

• Accession Number mRNA:

  NM_001165

• Chromosomal Location:

  11q22.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Apoptosis, Focal adhesion, NOD-like receptor signaling pathway, Pathways in cancer, Small cell lung cancer, Ubiquitin mediated proteolysis

• Field of Research:

  Apoptosis, Focal adhesion, NOD-like receptor signaling pathway, Pathways in cancer, Small cell lung cancer, Ubiquitin mediated proteolysis

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  68.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  BIRC3

• Species:

  Human

• Protein ID:

  NP_001156

• Overview:

  Recombinant protein of human baculoviral IAP repeat-containing 3 (BIRC3), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/330

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q13489

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001165

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001156