VPS4B (NM_004869) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16. [provided by RefSeq, Jul 2008]

• Synonyms:

  MIG1; SKD1; SKD1B; VPS4-2

• Gene ID:

  9525

• UniProt:

  O75351, A0A024R2C5

• Accession Number mRNA:

  NM_004869

• Chromosomal Location:

  18q21.33

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Endocytosis

• Field of Research:

  Endocytosis

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Transcription Factors

• Molecular Weight:

  49.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  VPS4B

• Species:

  Human

• Protein ID:

  NP_004860

• Overview:

  Recombinant protein of human vacuolar protein sorting 4 homolog B (S. cerevisiae) (VPS4B)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/9525

• Uniprot URL:

  https://www.uniprot.org/uniprot/O75351

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_004869

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_004860