LIN7C (NM_018362) Human Recombinant Protein

• Background:

  Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  LIN-7-C; LIN-7C; MALS-3; MALS3; VELI3

• Gene ID:

  55327

• UniProt:

  Q9NUP9

• Accession Number mRNA:

  NM_018362

• Chromosomal Location:

  11p14.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  21.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  LIN7C

• Species:

  Human

• Protein ID:

  NP_060832

• Overview:

  Recombinant protein of human lin-7 homolog C (C. elegans) (LIN7C)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/55327

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9NUP9

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_018362

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_060832