MMP14 (NM_004995) Human Recombinant Protein

• Background:

  Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]

• Synonyms:

  MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP; MT1MMP; MTMMP1; WNCHRS

• Gene ID:

  4323

• UniProt:

  P50281

• Accession Number mRNA:

  NM_004995

• Chromosomal Location:

  14q11.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  GnRH signaling pathway

• Field of Research:

  GnRH signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Protease, Transmembrane

• Molecular Weight:

  53.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  MMP14

• Species:

  Human

• Protein ID:

  NP_004986

• Overview:

  Recombinant protein of human matrix metallopeptidase 14 (membrane-inserted) (MMP14)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/4323

• Uniprot URL:

  https://www.uniprot.org/uniprot/P50281

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_004995

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_004986