CRMP2 (DPYSL2) (NM_001386) Human Recombinant Protein

• Background:

  This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

• Synonyms:

  CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3; ULIP-2; ULIP2

• Gene ID:

  1808

• UniProt:

  Q16555

• Accession Number mRNA:

  NM_001386

• Chromosomal Location:

  8p21.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Axon guidance

• Field of Research:

  Axon guidance

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Activity:

  29774780

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  62.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  DPYSL2

• Species:

  Human

• Protein ID:

  NP_001377

• Overview:

  Purified recombinant protein of Homo sapiens dihydropyrimidinase-like 2 (DPYSL2)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1808

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q16555

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001386

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001377