SOCS3 (NM_003955) Human Recombinant Protein

• Background:

  This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN) -gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]

• Synonyms:

  ATOD4; CIS3; Cish3; SOCS-3; SSI-3; SSI3

• Gene ID:

  9021

• UniProt:

  O14543, Q6FI39

• Accession Number mRNA:

  NM_003955

• Chromosomal Location:

  17q25.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Adipocytokine signaling pathway, Insulin signaling pathway, Jak-STAT signaling pathway, Type II diabetes mellitus, Ubiquitin mediated proteolysis

• Field of Research:

  Adipocytokine signaling pathway, Insulin signaling pathway, Jak-STAT signaling pathway, Type II diabetes mellitus, Ubiquitin mediated proteolysis

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  24.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  SOCS3

• Species:

  Human

• Protein ID:

  NP_003946

• Overview:

  Recombinant protein of human suppressor of cytokine signaling 3 (SOCS3)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/9021

• Uniprot URL:

  https://www.uniprot.org/uniprot/O14543

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_003955

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_003946