NKIRAS2 (NM_017595) Human Recombinant Protein

• Background:

  Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  KappaB-Ras2; KBRAS2

• Gene ID:

  28511

• UniProt:

  Q9NYR9, A0A024R1Z4

• Accession Number mRNA:

  NM_017595

• Chromosomal Location:

  17q21.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  21.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  NKIRAS2

• Species:

  Human

• Protein ID:

  NP_060065

• Overview:

  Recombinant protein of human NFKB inhibitor interacting Ras-like 2 (NKIRAS2), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/28511

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9NYR9

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_017595

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_060065