MADH7 (SMAD7) (NM_005904) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3) . Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

• Synonyms:

  CRCS3; MADH7; MADH8

• Gene ID:

  4092

• UniProt:

  O15105

• Accession Number mRNA:

  NM_005904

• Chromosomal Location:

  18q21.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  TGF-beta signaling pathway

• Field of Research:

  TGF-beta signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transcription Factors

• Molecular Weight:

  46.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  SMAD7

• Species:

  Human

• Protein ID:

  NP_005895

• Overview:

  Recombinant protein of human SMAD family member 7 (SMAD7)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/4092

• Uniprot URL:

  https://www.uniprot.org/uniprot/O15105

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_005904

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_005895