PDE4 (PDE4B) (NM_001037341) Human Recombinant Protein

• Background:

  This gene is a member of the type IV, cyclic AMP (cAMP) -specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

• Synonyms:

  DPDE4; PDEIVB

• Gene ID:

  5142

• UniProt:

  Q07343, X5DNX5

• Accession Number mRNA:

  NM_001037341

• Chromosomal Location:

  1p31.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Progesterone-mediated oocyte maturation, Purine metabolism

• Field of Research:

  Progesterone-mediated oocyte maturation, Purine metabolism

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  83.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PDE4B

• Species:

  Human

• Protein ID:

  NP_001032418

• Overview:

  Recombinant protein of human phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) (PDE4B), transcript variant d

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5142

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q07343

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001037341

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001032418