PDE4 (PDE4B) Mouse Monoclonal Antibody [Clone ID: LBI1D12]

• Background:

  This gene is a member of the type IV, cyclic AMP (cAMP) -specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

• Synonyms:

  DPDE4; PDE4B5; PDEIVB

• Gene Name:

  Phosphodiesterase 4B

• Gene ID:

  5142

• UniProt:

  Q07343

• Conjugation:

  Unconjugated

• Related Pathways:

  Progesterone-mediated oocyte maturation, Purine metabolism

• Field of Research:

  Progesterone-mediated oocyte maturation, Purine metabolism

• Concentration:

  0.62 mg/ml

• Dilution:

  WB 1:500~2000, IHC 1:150, IF 1:100, FLOW 1:100

• Form:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Buffer:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Function:

  Druggable Genome

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  PDE4B

• Overview:

  PDE4B mouse monoclonal antibody, clone LBI1D12

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=5142

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q07343