PTGIS (NM_000961) Human Recombinant Protein

• Background:

  This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]

• Synonyms:

  CYP8; CYP8A1; PGIS; PTGI

• Gene ID:

  5740

• UniProt:

  Q16647

• Accession Number mRNA:

  NM_000961

• Chromosomal Location:

  20q13.13

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Arachidonic acid metabolism, Metabolic pathways

• Field of Research:

  Arachidonic acid metabolism, Metabolic pathways

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Activity:

  28013348

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, P450, Transmembrane

• Molecular Weight:

  56.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PTGIS

• Species:

  Human

• Protein ID:

  NP_000952

• Overview:

  Recombinant protein of human prostaglandin I2 (prostacyclin) synthase (PTGIS)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5740

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q16647

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000961

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000952