TAS2R38 (NM_176817) Human Recombinant Protein

• Background:

  This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant) . [provided by RefSeq, Oct 2009]

• Synonyms:

  PTC; T2R38; T2R61; THIOT

• Gene ID:

  5726

• UniProt:

  P59533

• Accession Number mRNA:

  NM_176817

• Chromosomal Location:

  7q34

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Taste transduction

• Field of Research:

  Taste transduction

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  37.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  TAS2R38

• Species:

  Human

• Protein ID:

  NP_789787

• Overview:

  Recombinant protein of human taste receptor, type 2, member 38 (TAS2R38)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5726

• Uniprot URL:

  https://www.uniprot.org/uniprot/P59533

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_176817

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_789787