RIC8 (RIC8A) (NM_021932) Human Recombinant Protein

• Background:

  Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G (i) -alpha protein, possibly leading to release G (i) -alpha-GTP and NuMA proteins from the NuMA-GPSM2-G (i) -alpha-GDP complex (By similarity) . Also acts as an activator for G (q) -alpha (GNAQ) protein by enhancing the G (q) -coupled receptor-mediated ERK activation.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  RIC8

• Gene ID:

  60626

• UniProt:

  Q9NPQ8

• Accession Number mRNA:

  NM_021932

• Chromosomal Location:

  11p15.5

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  60.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  RIC8A

• Species:

  Human

• Protein ID:

  NP_068751

• Overview:

  Recombinant protein of human resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) (RIC8A)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/60626

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9NPQ8

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_021932

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_068751