TIP30 (HTATIP2) (NM_001098522) Human Recombinant Protein

• Background:

  Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  CC3; SDR44U1; TIP30

• Gene ID:

  10553

• UniProt:

  Q9BUP3

• Accession Number mRNA:

  NM_001098522

• Chromosomal Location:

  11p15.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  26.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  HTATIP2

• Species:

  Human

• Protein ID:

  NP_001091992

• Overview:

  Recombinant protein of human HIV-1 Tat interactive protein 2, 30kDa (HTATIP2), transcript variant 4

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/10553

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9BUP3

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001098522

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001091992