XRCC4 (NM_003401) Human Recombinant Protein

• Background:

  The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand breaks. This protein plays a role in both non-homologous end joining and the completion of V (D) J recombination. Mutations in this gene can cause short stature, microcephaly, and endocrine dysfunction (SSMED) . Alternate transcript variants such as NM_022406 are unlikely to be expressed in some individuals due to a polymorphism (rs1805377) in the last splice acceptor site. [provided by RefSeq, Oct 2019]

• Synonyms:

  SSMED

• Gene ID:

  7518

• UniProt:

  Q13426, A0A024RAL0, Q7Z763

• Accession Number mRNA:

  NM_003401

• Chromosomal Location:

  5q14.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Non-homologous end-joining

• Field of Research:

  Non-homologous end-joining

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  37.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  XRCC4

• Species:

  Human

• Protein ID:

  NP_003392

• Overview:

  Recombinant protein of human X-ray repair complementing defective repair in Chinese hamster cells 4 (XRCC4), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/7518

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q13426

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_003401

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_003392