Factor XI (F11) (NM_000128) Human Recombinant Protein

• Background:

  This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]

• Synonyms:

  FXI; PTA

• Gene ID:

  2160

• UniProt:

  P03951

• Accession Number mRNA:

  NM_000128

• Chromosomal Location:

  4q35.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Complement and coagulation cascades

• Field of Research:

  Complement and coagulation cascades

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Protease, Secreted Protein

• Molecular Weight:

  69.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  F11

• Species:

  Human

• Protein ID:

  NP_000119

• Overview:

  Recombinant protein of human coagulation factor XI (F11)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/2160

• Uniprot URL:

  https://www.uniprot.org/uniprot/P03951

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000128

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000119