MEMO1 (NM_015955) Human Recombinant Protein

• Background:

  May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  C2orf4; CGI-27; MEMO; NS5ATP7

• Gene ID:

  51072

• UniProt:

  Q9Y316

• Accession Number mRNA:

  NM_015955

• Chromosomal Location:

  2p22.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  33.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  MEMO1

• Species:

  Human

• Protein ID:

  NP_057039

• Overview:

  Recombinant protein of human mediator of cell motility 1 (MEMO1), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/51072

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9Y316

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_015955

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_057039