LD78 beta (CCL3L1) (NM_021006) Human Recombinant Protein

• Background:

  This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5) . CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility. This record represents one of two copies that are present on the ALT_REF_LOCI_2 alternate haplotype of the GRCh38 human reference genome assembly. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

• Synonyms:

  464.2; D17S1718; G0S19-2; LD78; LD78-beta (1-70) ; LD78BETA; MIP1AP; SCYA3L; SCYA3L1

• Gene ID:

  6349

• UniProt:

  P16619

• Accession Number mRNA:

  NM_021006

• Chromosomal Location:

  17q21.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Chemokine signaling pathway, Cytokine-cytokine receptor interaction

• Field of Research:

  Chemokine signaling pathway, Cytokine-cytokine receptor interaction

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Secreted Protein

• Molecular Weight:

  7.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CCL3L1

• Species:

  Human

• Protein ID:

  NP_066286

• Overview:

  Recombinant protein of human chemokine (C-C motif) ligand 3-like 1 (CCL3L1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/6349

• Uniprot URL:

  https://www.uniprot.org/uniprot/P16619

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_021006

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_066286