Caspase 9 (CASP9) (NM_032996) Human Recombinant Protein

• Background:

  This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

• Synonyms:

  APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56

• Gene ID:

  842

• UniProt:

  P55211

• Accession Number mRNA:

  NM_032996

• Chromosomal Location:

  1p36.21

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Endometrial cancer, Huntington's disease, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Parkinson's disease, Pathways in cancer, Prostate cancer, Small cell lung cancer, VEGF signaling pathway, Viral myocarditis

• Field of Research:

  Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Endometrial cancer, Huntington's disease, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Parkinson's disease, Pathways in cancer, Prostate cancer, Small cell lung cancer, VEGF signaling pathway, Viral myocarditis

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Protease, Stem cell - Pluripotency

• Molecular Weight:

  30 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CASP9

• Species:

  Human

• Protein ID:

  NP_127463

• Overview:

  Recombinant protein of human caspase 9, apoptosis-related cysteine peptidase (CASP9), transcript variant beta

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/842

• Uniprot URL:

  https://www.uniprot.org/uniprot/P55211

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_032996

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_127463