CTDSPL (NM_005808) Human Recombinant Protein

• Background:

  Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity) . Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  C3orf8; HYA22; PSR1; RBSP3; SCP3

• Gene ID:

  10217

• UniProt:

  O15194

• Accession Number mRNA:

  NM_005808

• Chromosomal Location:

  3p22.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Phosphatase

• Molecular Weight:

  29.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CTDSPL

• Species:

  Human

• Protein ID:

  NP_005799

• Overview:

  Recombinant protein of human CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like (CTDSPL), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/10217

• Uniprot URL:

  https://www.uniprot.org/uniprot/O15194

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_005808

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_005799