Ctdspl (NM_133710) Mouse Recombinant Protein

• Background:

  Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  2810418J22Rik; AI426263; HYA22; SCP3

• Gene ID:

  69274

• UniProt:

  P58465

• Accession Number mRNA:

  NM_133710

• Chromosomal Location:

  9 F3

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  31.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Ctdspl

• Species:

  Mouse

• Protein ID:

  NP_598471

• Overview:

  Purified recombinant protein of Mouse CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like (Ctdspl), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/69274

• Uniprot URL:

  https://www.uniprot.org/uniprot/P58465

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_133710

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_598471