TCF3 / E2A (TCF3) (NM_003200) Human Recombinant Protein

• Background:

  This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t (1;19), with PBX1), childhood leukemia (t (19;19), with TFPT) and acute leukemia (t (12;19), with ZNF384) . Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]

• Synonyms:

  AGM8; bHLHb21; E2A; E47; ITF1; p75; TCF-3; VDIR

• Gene ID:

  6929

• UniProt:

  P15923

• Accession Number mRNA:

  NM_003200

• Chromosomal Location:

  19p13.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transcription Factors

• Molecular Weight:

  67.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  TCF3

• Species:

  Human

• Protein ID:

  NP_003191

• Overview:

  Recombinant protein of human transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) (TCF3), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/6929

• Uniprot URL:

  https://www.uniprot.org/uniprot/P15923

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_003200

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_003191