Tcf3 (NM_011548) Mouse Recombinant Protein

• Background:

  Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  A1; AA408400; ALF2; AW209082; bHLHb21; E2A; E12; E12/E47; E47; KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a

• Gene ID:

  21423

• UniProt:

  P15806

• Accession Number mRNA:

  NM_011548

• Chromosomal Location:

  10 39.72 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  67.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Tcf3

• Species:

  Mouse

• Protein ID:

  NP_035678

• Overview:

  Purified recombinant protein of Mouse transcription factor 3 (Tcf3), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/21423

• Uniprot URL:

  https://www.uniprot.org/uniprot/P15806

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_011548

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_035678