ITGB1BP2 (NM_012278) Human Recombinant Protein

• Background:

  This gene encodes a protein with two cysteine and histidine-rich (CHORD) domains, PXXP motifs, YXXI/P motifs, putative SH2 and SH3 domain binding motifs, and an acidic region at the C-terminus that can bind calcium. Two hybrid analysis showed that this protein interacts with the cytoplasmic domain of the beta 1 integrin subunit and is thought to act as a chaperone protein. Studies in the mouse ortholog of this gene indicate that absence of this gene in mouse results in failed cardiac hypertrophy in response to mechanical stress. Alternative splicing results in multiple transcript variants encoding different isoforms, including an isoform that lacks several domains, including one of the CHORD domains. [provided by RefSeq, May 2017]

• Synonyms:

  CHORDC3; ITGB1BP; MELUSIN; MSTP015

• Gene ID:

  26548

• UniProt:

  Q9UKP3

• Accession Number mRNA:

  NM_012278

• Chromosomal Location:

  Xq13.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  38.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ITGB1BP2

• Species:

  Human

• Protein ID:

  NP_036410

• Overview:

  Recombinant protein of human integrin beta 1 binding protein (melusin) 2 (ITGB1BP2)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/26548

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9UKP3

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_012278

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_036410