Prostaglandin D Synthase (PTGDS) (NM_000954) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2) . PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]

• Synonyms:

  L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2

• Gene ID:

  5730

• UniProt:

  P41222, A0A024R8G3

• Accession Number mRNA:

  NM_000954

• Chromosomal Location:

  9q34.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Arachidonic acid metabolism, Metabolic pathways

• Field of Research:

  Arachidonic acid metabolism, Metabolic pathways

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  20.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PTGDS

• Species:

  Human

• Protein ID:

  NP_000945

• Overview:

  Recombinant protein of human prostaglandin D2 synthase 21kDa (brain) (PTGDS)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5730

• Uniprot URL:

  https://www.uniprot.org/uniprot/P41222

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000954

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000945