P15 INK4b (CDKN2B) (NM_078487) Human Recombinant Protein

• Background:

  This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

• Synonyms:

  CDK4I; INK4B; MTS2; P15; p15INK4b; TP15

• Gene ID:

  1030

• UniProt:

  P42772

• Accession Number mRNA:

  NM_078487

• Chromosomal Location:

  9p21.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Cell cycle, Pathways in cancer, Small cell lung cancer, TGF-beta signaling pathway

• Field of Research:

  Cell cycle, Pathways in cancer, Small cell lung cancer, TGF-beta signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  7.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CDKN2B

• Species:

  Human

• Protein ID:

  NP_511042

• Overview:

  Recombinant protein of human cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1030

• Uniprot URL:

  https://www.uniprot.org/uniprot/P42772

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_078487

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_511042