P15 INK4b (CDKN2B) Mouse Monoclonal Antibody [Clone ID: LBI3B6]

• Background:

  This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq]

• Synonyms:

  CDK4I; INK4B; MTS2; P15; p15INK4b; TP15

• Gene Name:

  Cyclin dependent kinase inhibitor 2B

• Gene ID:

  1030

• UniProt:

  P42772

• Conjugation:

  Unconjugated

• Related Pathways:

  Cell cycle, Pathways in cancer, Small cell lung cancer, TGF-beta signaling pathway

• Field of Research:

  Cell cycle, Pathways in cancer, Small cell lung cancer, TGF-beta signaling pathway

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:2000, IHC 1:150, FLOW 1:100

• Form:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Buffer:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Function:

  Druggable Genome

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  CDKN2B

• Overview:

  CDKN2B (p15 INK4b) mouse monoclonal antibody, clone LBI3B6

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=1030

• Uniprot URL:

  https://www.uniprot.org/uniprot/P42772