HCST (NM_001007469) Human Recombinant Protein

• Background:

  This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

• Synonyms:

  DAP10; KAP10; PIK3AP

• Gene ID:

  10870

• UniProt:

  Q9UBK5

• Accession Number mRNA:

  NM_001007469

• Chromosomal Location:

  19q13.12

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Natural killer cell mediated cytotoxicity

• Field of Research:

  Natural killer cell mediated cytotoxicity

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  7.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  HCST

• Species:

  Human

• Protein ID:

  NP_001007470

• Overview:

  Recombinant protein of human hematopoietic cell signal transducer (HCST), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/10870

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9UBK5

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001007469

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001007470