ADAM11 (NM_002390) Human Recombinant Protein

• Background:

  This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

• Synonyms:

  MDC

• Gene ID:

  4185

• UniProt:

  O75078

• Accession Number mRNA:

  NM_002390

• Chromosomal Location:

  17q21.31

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  83.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ADAM11

• Species:

  Human

• Protein ID:

  NP_002381

• Overview:

  Recombinant protein of human ADAM metallopeptidase domain 11 (ADAM11)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/4185

• Uniprot URL:

  https://www.uniprot.org/uniprot/O75078

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_002390

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_002381