UBE2V1 (TMEM189-UBE2V1) (NM_199203) Human Recombinant Protein

• Background:

  The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through transcript of the neighboring TMEM189 and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein produced by this transcript has UEV1 B domains but the protein is localized to the cytoplasm rather than to the nucleus. The significance of this read-through mRNA and the function of its protein product has not yet been determined. [provided by RefSeq, Oct 2010]

• Synonyms:

  CROC-1B; CROC1B; KUA-UEV; TMEM189-UBE2V1

• Gene ID:

  387522

• UniProt:

  Q13404, A5PLL7

• Accession Number mRNA:

  NM_199203

• Chromosomal Location:

  20q13.13

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Transmembrane

• Molecular Weight:

  42 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  TMEM189-UBE2V1

• Species:

  Human

• Protein ID:

  NP_954673

• Overview:

  Recombinant protein of human TMEM189-UBE2V1 readthrough transcript (TMEM189-UBE2V1), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/387522

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q13404

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_199203

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_954673