Ube2v1 (NM_023230) Mouse Recombinant Protein

• Background:

  Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation (By similarity) . Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  0610011J09Rik; AI256840; CROC-1; CROC1; D7Bwg1382e; UEV-1

• Gene ID:

  66589

• UniProt:

  Q9CZY3, Q569Y6

• Accession Number mRNA:

  NM_023230

• Chromosomal Location:

  2 87.44 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  16.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Ube2v1

• Species:

  Mouse

• Protein ID:

  NP_075719

• Overview:

  Purified recombinant protein of Mouse ubiquitin-conjugating enzyme E2 variant 1 (Ube2v1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/66589

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9CZY3

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_023230

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_075719