RNF14 (NM_183400) Human Recombinant Protein

• Background:

  The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]

• Synonyms:

  ARA54; HFB30; HRIHFB2038; TRIAD2

• Gene ID:

  9604

• UniProt:

  Q9UBS8

• Accession Number mRNA:

  NM_183400

• Chromosomal Location:

  5q31.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transcription Factors

• Molecular Weight:

  53.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  RNF14

• Species:

  Human

• Protein ID:

  NP_899647

• Overview:

  Recombinant protein of human ring finger protein 14 (RNF14), transcript variant 4

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/9604

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9UBS8

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_183400

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_899647