ASPA (NM_001128085) Human Recombinant Protein

• Background:

  This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

• Synonyms:

  ACY2; ASP

• Gene ID:

  443

• UniProt:

  P45381, Q6FH48

• Accession Number mRNA:

  NM_001128085

• Chromosomal Location:

  17p13.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Alanine, aspartate and glutamate metabolism, Histidine metabolism

• Field of Research:

  Alanine, aspartate and glutamate metabolism, Histidine metabolism

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  35.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ASPA

• Species:

  Human

• Protein ID:

  NP_001121557

• Overview:

  Recombinant protein of human aspartoacylase (Canavan disease) (ASPA), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/443

• Uniprot URL:

  https://www.uniprot.org/uniprot/P45381

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001128085

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001121557