SMAD6 (NM_001142861) Human Recombinant Protein

• Background:

  The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.[provided by RefSeq, Sep 2014]

• Synonyms:

  AOVD2; HsT17432; MADH6; MADH7

• Gene ID:

  4091

• UniProt:

  O43541

• Accession Number mRNA:

  NM_001142861

• Chromosomal Location:

  15q22.31

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  TGF-beta signaling pathway

• Field of Research:

  TGF-beta signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors

• Molecular Weight:

  26.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  SMAD6

• Species:

  Human

• Protein ID:

  NP_001136333

• Overview:

  Recombinant protein of human SMAD family member 6 (SMAD6), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/4091

• Uniprot URL:

  https://www.uniprot.org/uniprot/O43541

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001142861

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001136333